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Ageing is associated with a progressive decrease in skeletal muscle function, characterised by MU losses, muscle fibre atrophy (particularly type II) and fibre type grouping. Sarcopenic individuals display a compromised ability to perform everyday activities of daily living and are at increased risk of accidental falls, mainly due to decrements in muscle strength and power.

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The underlying signature of ageing, as manifested by perturbed redox homeostasis, leads to a blunting of acute and chronic redox regulated exercise adaptations. Impaired redox regulated exercise adaptations are mechanistically related to altered exercise-induced ROS/RNS generation and a resultant failure to properly activate redox regulated signaling cascades. Despite the specific impairments in redox signaling associated with ageing, physical activity, especially progressive RT or combined CV & RT, induces a plethora of beneficial effects. However, to derive the greatest long-term benefits of physical activity for slowing or reversing age-related decrements in skeletal muscle structure and function, it needs to be promoted as a lifelong habitual practice rather than just implemented in later life.


Therefore may add to the strong justification for promoting physical activity as a lifelong practice, rather than just trying to implement it late in life, when individuals have already succumbed to many of the maladies associated with ageing and a chronic habitual sedentary lifestyle.